
Drug Discovery
Medicinal Chemistry
The Research Network (TRN) offers an expert Medicinal Chemistry design service to progress your drug discovery programs from initial target evaluation and hit identification (HI), through lead optimisation (LO) and to candidate drug (CD) selection. Compound design and quality are led by our Medicinal Chemistry team with in-depth experience gained in both Pharma and Biotech R&D organisations.
We offer experience in Receptor, Enzyme, Peptide and Bio-conjugate drugs for oral, parenteral and inhaled delivery. Expert understanding of the properties to afford CDs with the desired PK profile and CMC characteristics. We advise on attrition with our in-house Attrition Knowledgebase, provide input into patent writing and Intellectual Property (IP) analysis and strategy.
With a wide range of expertise in our team of experienced medicinal chemists we are able to select the best expert for your needs and provide flexible scientific support as well as project management and leadership to your HI, LO and CD campaigns. We access a wide range of partner CRO’s to ensure the best-fit support for your project. Our experts cover many therapeutic areas: Cardiovascular; Metabolic Diseases; Respiratory; Inflammation; Oncology; Neuroscience; Dermatology and Virology; as well as large molecules approaches: Peptides and Bio-conjugation.
Synthetic Chemistry
The TRN Synthetic Chemistry Team specialise in providing expert support, consultancy, project management and design of bespoke solutions for your outsourcing research and synthethic strategy. We do not represent CROs but we are driven to finding the right partner to fit your project needs.
We deliver highly competitive quotes and flexible resource options in all areas including the following:
FFS (Fee For Service) or FTE (Full Time Employee) requests to deliver:
- Medicinal chemistry projects including the delivery of test compounds
- Synthetic intermediates including monomers and templates to support parallel medicinal chemistry efforts
- Re-syntheses, metabolites, reference standards
- Design of routes to difficult or speculative new chemistry
- API delivery including custom syntheses, solid form analysis and formulation support
- Bio conjugation strategy and synthesis
Parallel Medicinal Chemistry:
- Using a preferred highly cost-effective expert supplier using extensive in-house file of monomers or using your own bespoke compounds and commercial reagents.
CRO Project Management:
- Customised to meet the needs of the client, for one or multiple requests
- CRO metrics
- Cultural awareness, expertise working with India, China, America and Europe
Additional Services:
- Route design and selection including optimising the link between discovery and early clinical development phases
- Problem solving and technical trouble-shooting
- Assistance with shipping, communication, data transfer, software solutions to support logistics
- Import/Export logistics – Forms, HTS coding, couriers, customs
Biology
The TRN Biology team has over 70 years (collective) experience of working within the bio-pharmaceutical industry and academia to manage all aspects of biological research. Our team has extensive laboratory and leadership experience with numerous therapeutic areas including; oncology, pain, neuroscience, cardiovascular, respiratory disease, immunology, genitourinary, sexual health, inflammation and infection.
We also have extensive experience of managing the logistics of global biological research, operating multinational/multisite collaborative research projects, ensuring delivery of results, analysis/interpretation of data and all necessary legal documentation is in place.
Please click on the tabs below for more information about the additional support we offer:
Translational R&D
The TRN Translational R & D team has extensive experience integrating and applying discoveries generated during research in the laboratory, and in preclinical studies, to the design of clinical trials and studies in humans. The TRN team will work both with basic scientists to identify and investigate the clinical applications of their research, and with clinical scientists to formulate research studies based on their clinical observations.
The TRN Translational R & D team has broad cross-functional discovery and development experience using different therapeutic approaches across multiple therapeutic areas to identify and validate preclinical and clinical biomarkers.
The TRN Translational R & D team can also provide support in the following areas:
- Target/pathway expression analysis (gene, protein, miRNA)
- Functional validation via knockout, knockdown, or overexpression strategies
- Bioinformatics, molecular modeling and systems biology approaches
- Target validation using disease-relevant in vitro and in vivo models
- Interpreting PK/PD relationships for efficacy and safety assessment
- Assessing drug-drug interaction potential and risk mitigation strategies
- Formulation selection for POC studies in animals and humans
- – Interpretation of toxicology findings and their implications for clinical safety
- Human subject selection and clinical study design for initial POC
Utilize the broad therapeutic expertise of the TRN Translational R & D team:
- Biology, DMPK, toxicology, preclinical development, clinical pharmacology
- Small molecules, biologics and biotherapeutics, novel emerging therapeutic modalities
- Oncology, antiviral, respiratory, dermatology, cardiovascular-metabolic diseases
Utilize the TRN Translational R & D team to provide the following support:
- Strategic and technical advice to advance discovery leads to assess therapeutic potential
- Preparation of early development plans to support IND filings and initial clinical POC
- Development of risk assessment plans and risk mitigation strategies to support R & D
- Preparation and review of preclinical and clinical reports, and regulatory submissions
- Identification and management of CROs to support study-specific outsourcing needs
- Integrated project management from late discovery through early clinical development
Biologics & Biotherapeutics
The TRN Biologics and Biotherapeutics (B&B) team can enable all aspects of your biologic reagents and biotherapeutics development programs. Our network of experts has a long and proven track record in the creation of successful biologic drugs, having contributed to the development of numerous approved biopharmaceuticals. They understand the unique challenges in developing biotherapeutics and have an extensive knowledge of standard and new technologies. Whether your needs are simple, such as the development of tool proteins, or complex, such as the creation of biotherapeutic antibodies, our team will help you reach your goals.
The TRN B&B team can be engaged for multiple purposes including:
- De novo R&D projects
- Integrated management of external vendors
- Project consultation
- Due diligence to evaluate external assets
- Grant preparation
For de novo projects our experts will work with you to understand your objectives and plan your project strategy accordingly. We then source and manage all project activities, maintaining timelines and returning high quality deliverables. Along the way we provide all the biotherapeutics and project management expertise needed to rapidly and efficiently achieve your goals in the most cost effective manner. This provides our clients with budgetary flexibility that comes from not having to establish this expertise internally and allows them to focus precious time and resources on their own core competencies.
